Süsal, C., Hoffmann, G. W., Daniel, V., Grant, M. D. and Opelz, G. "Complementarities and Network Interactions in AIDS".  J. Autoimmunity, 6, 601-610, 1993.

 

Two groups of molecules (Group I and Group II) are defined on the basis of their relationships to MHC-I and MHC-II. Group I is similar to MHC I or complementary to MHC II, while Group II is similar to MHC II or complementary to MHC I. HIV immune sera contain Group I antibodies, including anti-Fab and anti-gp120, and Group II antibodies, including anti-anti-gp120, anti-anti-CD8 and anti-recombinant CD4. An inverse correlation over time is observed between the levels of Group I antibodies relative to Group II antibodies in HIV infected persons, and a positive correlation is observed between the levels of different Group II antibodies. This is interpreted as being due to Group I and Group II lymphocytes being mutually regulatory. It is consistent with pathogenesis involving both MHC image and anti-MHC antibodies, as postulated in the symmetric network theory of AIDS pathogenesis.