Cooper-Willis, A. and Hoffmann, G.W.
"Symmetry of Effector Function in the Immune System Network", Mol.
Immunol., 20, (8), 865-870 (1983).
Symmetry in stimulation was well established
at a time when symmetry in killing, while plausible, had not been demonstrated
experimentally. This paper describes an experiment in which two mutually
monoclonal antibodies were used to demonstrate symmetric killing. The paper
also demonstrates multispecificity, since one of the antibodies (the
"idotype") kills not only cells with the complementary antibody
("antiidiotype") attached, but also target cells that have a
structurally unrelated hapten attached to them.